Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A3501" target="_blank" >RIV/00216208:11110/09:3501 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/09:3501

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Changes in the localization of collagens IV and VIII in corneas obtained from patients with posterior polymorphous corneal dystrophy

Original language description

The aim of this study was to determine the changes in the presence and localization of the ?1 ? ?6 collagen IV and ?1, ?2 collagen VIII chains in Czech patients with posterior polymorphous corneal dystrophy (PPCD). Twelve corneal buttons from ten PPCD patients as well as eight control corneas were used and enzymatic indirect immunohistochemistry was performed. More than 50% of PPCD specimens exhibited positivity for ?1 and ?2 collagen IV chains in the basal membrane of the epithelium and in the posterior stroma, while no staining was detected in controls. The ?1 collagen VIII chain was detected on the endothelial and stromal sides of Descemet?s membrane (DM), compared with the prevailing localization on the stromal side of DM in control corneas. The increased expression and the change in localization of the ?1, ?2 collagen IV and ?1 collagen VIII chains may contribute to the increased endothelial proliferative capacity observed in PPCD patients.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Eye Research

ISSN

0014-4835

e-ISSN

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Volume of the periodical

88

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

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UT code for WoS article

000265898400011

EID of the result in the Scopus database

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