Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in lewis rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A4715" target="_blank" >RIV/00216208:11110/09:4715 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/09:00330845 RIV/00216208:11120/09:00001687 RIV/00064165:_____/09:4715

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in lewis rats

Original language description

Objective: Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY), which is mainly under the dual control of leptin and ghrelin. Rat adjuvant arthritis (AA), similarly as human rheumatoid arthritis, is associated with cachexia caused byyet unknown mechanisms. The aim of our study was to evaluate NPY expression in hypothalamic arcuate nuclei (nARC) under the conditions of AA- induced changes in leptin, ghrelin and adiponectin. Since IL-1 beta is involved in the central induction of anorexia, we studied its expression in the nARC as well. Methods: AA was induced to Lewis rats using complete Freund's adjuvant. On days 12, 15 and 18 after complete Freund's adjuvant injection, the levels of leptin, adiponectin, ghrelin and IL-1 beta weredetermined by RIA or ELISA. The mRNA expressions for NPY, leptin receptor (OB-R), ghrelin receptor (Ghsr) and IL-1 beta were determined by TaqMan RT-PCR from isolated nARC.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

<a href="/en/project/GA305%2F06%2F0427" target="_blank" >GA305/06/0427: Nutritional modulation of adjuvant arthritis in rats: interplay of leptin and ghrelin</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroimmunomodulation

ISSN

1021-7401

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

6

Country of publishing house

CH - SWITZERLAND

Number of pages

8

Pages from-to

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UT code for WoS article

000270364500002

EID of the result in the Scopus database

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