Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A6825" target="_blank" >RIV/00216208:11110/10:6825 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/10:6825

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Mitochondrial DNA content and expression of genes involved in mtDNA transcription, regulation and maintenance during human fetal development

Original language description

The mitochondrial biogenesis and adequate energy production are important for fetal growth and early postnatal adaptation. The aim of the study was to characterize mitochondrial DNA (mtDNA) content and expression patterns of POLG, TFAM, NRF1,NRF2 and PGC1 family of regulated coactivators (PGC1A, PGC1B and PRC), COX4 and MTCO2 in human fetal tissues during gestation. Moreover enzyme activities of COX and CS and protein levels of cytochrome c oxidase (COX) subunits were analysed. DNA, RNA and proteins were isolated from 26 pairs of fetal liver and muscle samples between 13th and 28th week of gestation. This work offers a broad view on the differences in expression of POLG, TFAM, NRF2 genes and family PGC1 coactivators found between the fetal tissues. Thesignificant tissue-specific changes in expression of selected COX subunits on mRNA level were observed. The considerable differences in enzyme activities of COX and CS are demonstrated between fetal and postnatal phase. In conclusion our

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mitochondrion

ISSN

1567-7249

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

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UT code for WoS article

000278262600003

EID of the result in the Scopus database

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