Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A6853" target="_blank" >RIV/00216208:11110/10:6853 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/10:6853
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Assembly factors and ATP- dependent proteases in cytochrome c oxidase biogenesis
Original language description
Cytochrome c oxidase (CcO) is the terminal enzyme of the energy-transducing mitochondrial electron transport chain. It is a hetero-oligomeric complex composed of both mitochondrially and nuclear-encoded subunits. The biogenesis of CcO is sequential process that requires numerous specific accessory proteins, so-called assembly factors, which include translational activators, translocases, molecular chaperones, copper metallochaperones and heme a biosynthetic enzymes. In addition, the correct biogenesis of CcO requires an even greater number of proteins with broader substrate specificities. Indeed, mitochondrial ATP-dependent proteases might play an important role in CcO biogenesis. Out of the four identified energy dependent mitochondrial proteases, three were shown to be involved in proteolysis of CcO subunits. Besides their protein-quality control function these oligomeric complexes may function as molecular chaperones promoting productive folding and assembly of CcO subunits.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biochimica et Biophysica Acta - Bioenergetics
ISSN
0005-2728
e-ISSN
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Volume of the periodical
1797
Issue of the periodical within the volume
6-7
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
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UT code for WoS article
000279663200066
EID of the result in the Scopus database
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