All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7080" target="_blank" >RIV/00216208:11110/10:7080 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/10:6280 RIV/00064203:_____/10:6280 RIV/00064165:_____/10:7080

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease

  • Original language description

    The CTLA4 gene is associated with several immunopathologic diseases and because of its important immuno-regulatory role it may be considered also a plausible candidate for a genetic association with inflammatory bowel diseases. The aim of this study wasto assess the association in the Czech population, using a set of markers shown to associate with other diseases. No crude associations with Crohn's disease were found for the tested CTLA4 variants under the log-additive or dominant models. However, a protective effect of a CTLA4 haplotype was unmasked after stratification for the risk variants in the NOD2 and IL23R genes, and may point towards the biological relevance of the molecule in the pathogenesis of the disease.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FE - Other fields of internal medicine

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9219" target="_blank" >NR9219: The effect of genotype/fenotype pattern on the disease course and on the therapeutic response in patients with ulcerative colitis and Crohn´s disease (IBD)</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BMC Medical Genetics

  • ISSN

    1471-2350

  • e-ISSN

  • Volume of the periodical

    11

  • Issue of the periodical within the volume

    a.n.91

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    9

  • Pages from-to

  • UT code for WoS article

    000279920800002

  • EID of the result in the Scopus database