The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7080" target="_blank" >RIV/00216208:11110/10:7080 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/10:6280 RIV/00064203:_____/10:6280 RIV/00064165:_____/10:7080
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The CTLA4 variants may interact with the IL23R-and NOD2-conferred risk in development of Crohn's disease
Original language description
The CTLA4 gene is associated with several immunopathologic diseases and because of its important immuno-regulatory role it may be considered also a plausible candidate for a genetic association with inflammatory bowel diseases. The aim of this study wasto assess the association in the Czech population, using a set of markers shown to associate with other diseases. No crude associations with Crohn's disease were found for the tested CTLA4 variants under the log-additive or dominant models. However, a protective effect of a CTLA4 haplotype was unmasked after stratification for the risk variants in the NOD2 and IL23R genes, and may point towards the biological relevance of the molecule in the pathogenesis of the disease.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NR9219" target="_blank" >NR9219: The effect of genotype/fenotype pattern on the disease course and on the therapeutic response in patients with ulcerative colitis and Crohn´s disease (IBD)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BMC Medical Genetics
ISSN
1471-2350
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
a.n.91
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
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UT code for WoS article
000279920800002
EID of the result in the Scopus database
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