Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7266" target="_blank" >RIV/00216208:11110/10:7266 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics

Original language description

Two common chemotherapeutic agents, Ifosfamide and cyclophosphamide, are isomers, bu only ifosfamide is known to cause nephrotoxicity and neurotoxicity. UPLC-ESI-QT0FMS-based metabolomics revealed five novel metabolites. The results suggest that precursors of thiodiglycolic acid, may be responsible for Ifosfamide encephalopathy and nephropathy.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BIOCHEMICAL PHARMACOLOGY

ISSN

0006-2952

e-ISSN

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Volume of the periodical

80

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

12

Pages from-to

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UT code for WoS article

000281428800014

EID of the result in the Scopus database

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