Infrared pupilometry as a biomarker of drug effects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7587" target="_blank" >RIV/00216208:11110/10:7587 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/10:7587

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Infračervená pupilometrie jako biomarker efektu léků

Original language description

Measurement of the size of the pupil is used as a biomarker of drug efficacy. The aim of our study was to evaluate sensitivity of various pupilometric parameters as biomarkers of widely used opioid analgesic drug tramadol. Pharmacodynamic action was studied in 60 healthy volunteers. Commercially available infrared pupilometer 'Pupilscan II' was used for the measurements of static and dynamic pupilometric parameters prior the dosing and 2.5 hours afterwards. Drug-induced decreases of the initial diameter(0, 49 mm) a final diameter (0, 38 mm) were significant in the right eye, as well as in left eye. Our results confirm the use of pupilometric as an objective, non-invasive tool for evaluation of pharmacodynamic activity of drugs.

Czech name

Infračervená pupilometrie jako biomarker efektu léků

Czech description

Measurement of the size of the pupil is used as a biomarker of drug efficacy. The aim of our study was to evaluate sensitivity of various pupilometric parameters as biomarkers of widely used opioid analgesic drug tramadol. Pharmacodynamic action was studied in 60 healthy volunteers. Commercially available infrared pupilometer 'Pupilscan II' was used for the measurements of static and dynamic pupilometric parameters prior the dosing and 2.5 hours afterwards. Drug-induced decreases of the initial diameter(0, 49 mm) a final diameter (0, 38 mm) were significant in the right eye, as well as in left eye. Our results confirm the use of pupilometric as an objective, non-invasive tool for evaluation of pharmacodynamic activity of drugs.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Časopis lékařů českých

ISSN

0008-7335

e-ISSN

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Volume of the periodical

149

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

3

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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