Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7704" target="_blank" >RIV/00216208:11110/10:7704 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/10:7704
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
Original language description
Cystathionine beta-synthase knockout mouse exhibits severe liver injury that is not found in the human cystathionine beta-synthase deficiency (homocystinuria) disease. The hepatopathy observed in this model may offer an explanation for the failure of cbs(-/-) mice to respond to betaine or exhibit a hypercoagulative phenotype. It is concluded that although this model provides useful data on the biochemical sequelae of classical homocystinuria, it does not successfully recapitulate a number of importantfeatures of the human disease and its use for studying mechanisms in homocystinuria should be treated with caution as the hepatopathy produces changes which could influence the results.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecular Genetics and Metabolism
ISSN
1096-7192
e-ISSN
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Volume of the periodical
101
Issue of the periodical within the volume
2.III
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
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UT code for WoS article
000283609600013
EID of the result in the Scopus database
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