Differential display code 3 (DD3/PCA3) in prostate cancer diagnosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8398" target="_blank" >RIV/00216208:11110/10:8398 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/10:6541 RIV/00216208:11140/10:00300026 RIV/00669806:_____/10:00300714 RIV/00064203:_____/10:6541 RIV/00064165:_____/10:8398

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Differential display code 3 (DD3/PCA3) in prostate cancer diagnosis

Original language description

Early diagnosis of prostate cancer (PCa) in an organ-confined stage following radical treatment is the only potential curative approach in PCa. Prostatic-specific antigen (PSA) is very helpful in early diagnosis, but the main disadvantage is that it hasa low positive predictive value in the range of the grey zone of 2.5-10 ng/mL. For this reason, new tests with better parameters are needed. One promising test is that for differential display code 3 (DD3(PCA3)), which is a prostate-specific non-coding mRNA that is highly overexpressed in prostate tumor cells. A total of 186 patients were examined. In a group of patients with suspected PCa, one tissue specimen core was collected for testing DD3(PCA3) expression. The total RNA was isolated and DD3(PCA3)and PSA expressions were quantified using quantitative RT real-time PCR method. It was found that the levels of the mRNA expression of DD3(PCA3) were significantly higher (p<0.045) in patients with PCa than in patients with benign prostat

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FJ - Surgery including transplantology

OECD FORD branch

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Project

<a href="/en/project/NR8918" target="_blank" >NR8918: DD3, a New Tumor Marker For Gene Early Diagnostic Of Prostate Cancer</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Anticancer Research

ISSN

0250-7005

e-ISSN

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Volume of the periodical

30

Issue of the periodical within the volume

2

Country of publishing house

GR - GREECE

Number of pages

6

Pages from-to

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UT code for WoS article

000275821200059

EID of the result in the Scopus database

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