The serotonin transporter gene (5-HTT) variant and psychiatric disorders
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8647" target="_blank" >RIV/00216208:11110/10:8647 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/10:8647
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The serotonin transporter gene (5-HTT) variant and psychiatric disorders
Original language description
Serotonin transporter plays an important role in serotogenic transmisssion and the serotonin transporter gene is under investigation in connection with many psychiatric disorders. There are two main genetic variations in the promoter region of the gene -long (L) allele and a short (S). The S allele is associated with decreased transcriptional efficiency of the promoter leads to reduced serotonin re-uptake in comparison to the long allele which is associated with greater gene expression. The length of polymorphisms are considered to be important mediators of emotional instability and predisposition to mental illness, high trait anxiety, fear-related behavior, negative emotions. The serotonin transporter gene has received much attention in association with psychiatric disorders and its explication can improve understanding to its principles.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neuroendocrinology Letters
ISSN
0172-780X
e-ISSN
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Volume of the periodical
31
Issue of the periodical within the volume
1
Country of publishing house
SE - SWEDEN
Number of pages
7
Pages from-to
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UT code for WoS article
000288581900002
EID of the result in the Scopus database
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