ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10262" target="_blank" >RIV/00216208:11110/11:10262 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:6948 RIV/00064203:_____/11:6948 RIV/00064165:_____/11:10262
Result on the web
<a href="http://dx.doi.org/10.1182/blood-2010-09-309070" target="_blank" >http://dx.doi.org/10.1182/blood-2010-09-309070</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
ETV6/RUNX1 (TEL/AML1) is a frequent prenatal first hit in childhood leukemia
Original language description
Between 1998 and 2002, we analyzed the cord blood of 253 healthy newborns for the presence of TEL/AML1 (n=253), MLL/AF4 (n=103), and BCR/ABL (n=103) fusion transcripts using standard end-point reverse transcription?polymerase chain reaction (RT-PCR; 197samples) or quantitative RT-PCR (TEL/ AML1 only; 56 samples). While all tested samples proved to be BCR/ABL and MLL/AF4 negative we found that of the cord blood tested, 5 of 253 (2%) bore the TEL/AML1 fusion. Moreover, we tested tissues taken from aborted fetuses (1 x spleen, 11 x liver) for the presence of TEL/AML1 and we found the spleen tissue positive (abortion for sepsis in 29th week of gestation). We have several reasons to consider the positively tested samples genuinely positive rather than contaminated.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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