Thermoresponsive polymeric radionuclide delivery system-An injectable brachytherapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10302" target="_blank" >RIV/00216208:11110/11:10302 - isvavai.cz</a>
Alternative codes found
RIV/61389005:_____/11:00359030 RIV/61389013:_____/11:00359030
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejps.2011.02.002" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2011.02.002</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Thermoresponsive polymeric radionuclide delivery system-An injectable brachytherapy
Original language description
Brachytherapy is of increasing popularity in clinical oncology for the local therapy of solid tumors due to high radiation doses delivered to malignant tissue while keeping the whole-body radiation burden low. Pronounced dose-dependent tumor growth reduction was achieved by single dose of injectable intratumoral brachytherapy with iodine-131-labeled thermoresponsive polymer [poly(N-isopropyl acrylamide)] in murine xenograft model (PC3 human prostate adenocarcinoma). The two doses of radionuclide were used, 2 MBq/mouse and 25 MBq/mouse. The higher dose caused gradual tumor volume reduction and 2 of 6 mice from this group were cured.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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