HPV involvement in tonsillar cancer: prognostic significance and clinically relevant markers

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10693" target="_blank" >RIV/00216208:11110/11:10693 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7005 RIV/00064203:_____/11:7005 RIV/00023736:_____/11:00009046
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.25889" target="_blank" >http://dx.doi.org/10.1002/ijc.25889</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
HPV involvement in tonsillar cancer: prognostic significance and clinically relevant markers
Original language description
The association of high-risk human papillomaviruses (HR HPVs) with tonsillar cancer (TC) has been documented. Because patients with HPV-associated tumors show better survival rates, modification of their treatment regimen is being considered. It is therefore crucial to find markers for the identification of patients whose tumors are linked to viral infection. A cohort of 109 patients with primary TC was screened for HPV DNA presence in the tumor tissues and HPV-specific antibodies in sera. Data regarding risk factors and clinical parameters were collected. Forty-five specimens were analyzed for the expression of viral E6 and E2-region mRNA, and the p16 and p53 protein expression status was assessed by immunohistochemistry. The overall prevalence of HPVDNA in TC tissues was 65.1%. Ninety-three percent of HR HPV DNA-positive samples expressed E6*I mRNA. E2-region mRNA expression was detected in 36% of positive samples, which implies that the virus is integrated in 64% of HPV DNA/RNA-pos
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Project
<a href="/en/project/NR9466" target="_blank" >NR9466: Use of virologic markers in the treatment and prevention of oral and oropharyngeal cancer</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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