The problems of proteinuria measurement in urine with presence of Bence Jones protein

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A11278" target="_blank" >RIV/00216208:11110/11:11278 - isvavai.cz</a>

Alternative codes found

RIV/60162694:G44__/11:00002484 RIV/00216208:11150/11:10105440 RIV/65269705:_____/11:#0001320 RIV/00179906:_____/11:10105440 and 2 more

Result on the web

<a href="http://dx.doi.org/10.1016/j.clinbiochem.2011.01.008" target="_blank" >http://dx.doi.org/10.1016/j.clinbiochem.2011.01.008</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The problems of proteinuria measurement in urine with presence of Bence Jones protein

Original language description

Objectives: Protein concentration measurement in the urine can be problematic in the presence of Bence Jones protein. We have carried out an external quality control assessment with the participation of 79 clinical biochemistry laboratories from the Czech Republic and Slovakia. Design and methods: The laboratories received a reference urine sample obtained from a patient with multiple myeloma and lambda free light chain proteinuria and were asked to type the paraprotein using immunofixation and to measure total urinary protein using their established method, most commonly turbidimetry, pyrogallol red assay, and biuret assay. Results: There was a very wide inter-laboratory variability in the protein concentration readouts with up to three-fold difference in some cases. High-resolution two-dimensional electrophoresis and linear mass spectrometry showed that a high proportion of the urinary paraprotein was composed of lambda light chain fragments with molecular weight of 12 kDa. Conclusio

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

5

Country of publishing house

CA - CANADA

Number of pages

3

Pages from-to

403-405

UT code for WoS article

000288845000010

EID of the result in the Scopus database

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