Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9001" target="_blank" >RIV/00216208:11110/11:9001 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1600-0897.2010.00923.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0897.2010.00923.x</a>
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Methods for Evaluation of Humoral Immune Responses in Human Genital Tract Secretions
Original language description
The compilation of epidemiological, virological, and immunological data clearly indicates that HIV-1 infection must be considered primarily as a disease of the mucosal immune system. The earliest and most dramatic alterations of the immune system occur in the mucosal compartment. However, the mucosal immune systems of the genital and intestinal tracts display remarkable immunological differences that must be considered in the evaluation of humoral immune responses in HIV-1-infected individuals or in volunteers immunized with experimental HIV vaccines. In this regard, marked differences in the dominant Ig isotypes, molecular forms of HIV-1-specific antibodies, and their distinct effector functions in the genital versus intestinal tracts must be carefully evaluated and considered in the measurement and interpretation of humoral immune responses.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)