Behavioral, hyperthermic and pharmacokinetic profile of para-methoxymethamphetamine (PMMA) in rats

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9268" target="_blank" >RIV/00216208:11110/11:9268 - isvavai.cz</a>
Alternative codes found
RIV/00023752:_____/11:00001136 RIV/00216208:11120/11:00002934 RIV/00064165:_____/11:9268
Result on the web
<a href="http://dx.doi.org/10.1016/j.pbb.2010.12.011" target="_blank" >http://dx.doi.org/10.1016/j.pbb.2010.12.011</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Behavioral, hyperthermic and pharmacokinetic profile of para-methoxymethamphetamine (PMMA) in rats
Original language description
Herein we present the behavioral profile of PMMA, its hyperthermic potency and pharmacokinetic profile in rats. The effects of PMMA 5 and 20 mg/kg on locomotion, on prepulse inhibition (PPI) of acoustic startle reaction (ASR), on body temperature under isolated and crowded conditions and on the pharmacokinetics analyzed with gas-chromatography mass spectrometry (GC-MS) were evaluated. Pmma increased overall locomotion with the higher dose showing biphasic effect. PPI was decreased dose-dependently. Thehyperthermic response was present only with PMMA 20 mg/kg and was accompanied by extensive perspiration under crowded conditions.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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