Impaired Deoxyribonuclease I Activity in Patients with Inflammatory Bowel Diseases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9431" target="_blank" >RIV/00216208:11110/11:9431 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/11:9431
Result on the web
<a href="http://dx.doi.org/10.4061/2011/945861" target="_blank" >http://dx.doi.org/10.4061/2011/945861</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Impaired Deoxyribonuclease I Activity in Patients with Inflammatory Bowel Diseases
Original language description
Deoxyribonuclease I (DNaseI) is an endonuclease that facilitates chromatin breakdown and promotes susceptibility to autoimmune disorders. The aim of current study was to investigate serum DNase I activity in patients with inflammatory bowel diseases (IBD). Patients and Methods. A cohort of 110 IBD patients was evaluated, aged 35 +/- 12 years, 77 with Crohn?s disease (CD) and 33 with ulcerative colitis (UC). 50 SLE patients and 50 healthy blood donors were examined as control groups. Results. DNase I activity in IBD patients was significantly lower than in healthy individuals, but higher than in SLE patients (P < .0001). Patients with UC showed higher DNase I activity than CD patients, P = .21. DNase I activity in female patients with IBD was significantly lower than in males, P = .024; however, no differences in DNase I activity were found in relation to gender in healthy individuals. DNase I activity has shown a strong negative correlation with the serum concentration of anti-nucleoso
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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