Two independent genetic factors responsible for the associations of the IBD5 locus with Crohn's disease in the Czech population.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9464" target="_blank" >RIV/00216208:11110/11:9464 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/11:7045 RIV/00064203:_____/11:7045 RIV/00064165:_____/11:9464

Result on the web

<a href="http://dx.doi.org/10.1002/ibd.21532" target="_blank" >http://dx.doi.org/10.1002/ibd.21532</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Two independent genetic factors responsible for the associations of the IBD5 locus with Crohn's disease in the Czech population.

Original language description

The role of the IBD5 locus in development of Crohn's disease (CD) has not been clarified. In the Czech population we examined its genetic association using variants of the SLC22A4 (rs1050152), SLC22A5 (rs2631367), two single nucleotide polymorphisms (SNPs) shown to be associated with CD in genome-wide studies (rs6596075 and rs2188962), and four SNPs previously shown to tag the haplotype blocks 4, 7, 9, 10 of the IBD5 locus (IGR2063b_1, IGR2230a_1, IGR100Xa_1, IGR3236a_1). The genotype, phenotype, and allelic frequencies were compared between 469 unrelated patients with CD (177 pediatric-onset, 292 adult-onset) and 470 unrelated healthy controls, all Caucasians of Czech ancestry. The most significant difference between patients and controls was found for the SNP rs6596075 (odds ratio [OR] = 0.70 for the G allele; 95% CI 0.52-0.94) in the dominant model and SNP IGR2063b_1 (OR = 1.38 for the G allele; 95% CI 1.14-1.67) in the log-additive model. We found a strong linkage disequilibrium ac

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammatory Bowel Diseases

ISSN

1078-0998

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1523-1529

UT code for WoS article

000292415200007

EID of the result in the Scopus database

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