Quantitative brain MR imaging in amyotrophic lateral sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A9529" target="_blank" >RIV/00216208:11110/11:9529 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/11:00002925 RIV/00064190:_____/11:#0000252 RIV/00064165:_____/11:9529
Result on the web
<a href="http://dx.doi.org/10.1007/s10334-010-0237-4" target="_blank" >http://dx.doi.org/10.1007/s10334-010-0237-4</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Quantitative brain MR imaging in amyotrophic lateral sclerosis
Original language description
To evaluate the potential of quantitative MR techniques [voxel-based morphometry (VBM), T2-relaxometry, mean diffusivity (MD), fractional anisotropy (FA)] in the diagnostics of amyotrophic lateral sclerosis (ALS). Thirty-three ALS patients and thirty age- and sex-matched healthy volunteers were included in the cross-sectional study. T1WI, T2WI and T2 relaxometry sequences were performed at 1.5T. DWI was performed in a subgroup of 12 patients. Disease severity was estimated with the ALS Functional RatingScale (ALS-FRS). We detected decreased T2 relaxation rate (R2) in the frontal white matter (FWM) (left and right P < 0.005) and caudate nucleus (left P < 0.005) in ALS patients. R2 in the FWM correlated with age in patients and controls. A correlation (P < 0.01, cluster-level corrected) between atrophy in the corona radiata and the limb ALS-FRS subset was found, as well as a difference between patients and controls in this area. No correlation between FA/MD and ALS-FRS was observed in t
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Magnetic Resonance Materials in Physics, Biology and Medicine
ISSN
0968-5243
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
67-76
UT code for WoS article
000288759200002
EID of the result in the Scopus database
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