Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11362" target="_blank" >RIV/00216208:11110/12:11362 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/12:11362

Result on the web

<a href="http://dx.doi.org/10.5665/sleep.2080" target="_blank" >http://dx.doi.org/10.5665/sleep.2080</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Predictors of Hypocretin (Orexin) Deficiency in Narcolepsy Without Cataplexy

Original language description

Measurements and Results: The optimal cutoff of CSF hypocretin-1 for narcolepsy without cataplexy diagnosis was 200 pg/ml rather than 110 pg/ml (sensitivity 33%, specificity 99%). Forty-one patients (24%), all HLA DQB1*06:02 positive, had low concentrations (<= 110 pg/ml) of CSF hypocretin-1. Patients with low concentrations of hypocretin-1 only differed subjectively from other groups by a higher Epworth Sleepiness Scale score and more frequent sleep paralysis. Compared with patients with normal hypocretin-1 concentration (n = 117, 68%), those with low hypocretin-1 concentration had higher HLA DQB1*06:02 frequencies, were more frequently non-Caucasians (notably African Americans), with lower age of onset, and longer duration of illness. They also had more frequently short rapid-eye movement (REM) sleep latency (<= 15 min) during polysomnography (64% versus 23%), and shorter sleep latencies (2.7 +/- 0.3 versus 4.4 +/- 0.2 min) and more sleep-onset REM periods (3.6 +/- 0.1 versus 2.9 +/-

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Sleep

ISSN

0161-8105

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

9

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1247-1255

UT code for WoS article

000308360100012

EID of the result in the Scopus database

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