Hypoxia-Induced Lipid Peroxidation in the Brain During Postnatal Ontogenesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11535" target="_blank" >RIV/00216208:11110/12:11535 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/12:00380085

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Hypoxia-Induced Lipid Peroxidation in the Brain During Postnatal Ontogenesis

Original language description

Reactive oxygen species (ROS) are common products of the physiological metabolic reactions, which are associated with cell signaling and with the pathogenesis of various nervous disorders. The brain tissue has the high rate of oxidative metabolic activity, high concentration of polyunsaturated fatty acids in membrane lipids, presence of iron ions and low capacity of antioxidant enzymes, which makes the brain very susceptible to ROS action and lipid peroxidation formation. Membranes of brain cortex showa higher production of thiobarbituric acid-reactive substances (TBARS) in prooxidant system (ADP center dot Fe3+/NADPH) than membranes from the heart or kidney. Lipid peroxidation influences numerous cellular functions through membrane-bound receptors orenzymes. The rate of brain cortex Na+,K+-ATPase inhibition correlates well with the increase of TBARS or conjugated dienes and with changes of membrane fluidity. The experimental model of short-tern hypoxia (simulating an altitude of 900

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

61

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

13

Pages from-to

"S89"-"S101"

UT code for WoS article

000307133700006

EID of the result in the Scopus database

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