Plasma mannose-binding lectin is stimulated by PPAR alpha in humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11555" target="_blank" >RIV/00216208:11110/12:11555 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:11555
Result on the web
<a href="http://dx.doi.org/10.1152/ajpendo.00299.2011" target="_blank" >http://dx.doi.org/10.1152/ajpendo.00299.2011</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Plasma mannose-binding lectin is stimulated by PPAR alpha in humans
Original language description
The peroxisome proliferator activated receptor-alpha (PPAR alpha) is a major transcriptional regulator of lipid metabolism in liver and represents the molecular target for hypolipidemic fibrate drugs. Effects of PPAR alpha on lipid metabolism are partially mediated by circulating proteins such as FGF21 and ANGPTL4. The present study was undertaken to screen for and identify circulating proteins produced by human liver that are under the control of PPAR alpha. Toward that aim, primary human hepatocytes were treated with the synthetic PPAR alpha agonist Wy-14643 and whole genome expression data selected for secreted proteins. Expression of FGF21, ANGPTL4, and mannose-binding lectin (MBL), a soluble mediator of innate immunity and primary component of thelectin branch of the complement system, was markedly upregulated by Wy-14643 in primary human hepatocytes. Mice express two MBL isomers, Mbl1 and Mbl2. Mbl1 mRNA was weakly induced by Wy-14643 in primary mouse hepatocytes and remained un
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Physiology - Endocrinology and Metabolism
ISSN
0193-1849
e-ISSN
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Volume of the periodical
302
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"E595"-"E602"
UT code for WoS article
000300723500012
EID of the result in the Scopus database
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