In vitro inhibition of mitochondrial respiratory rate by antidepressants

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11658" target="_blank" >RIV/00216208:11110/12:11658 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.toxlet.2012.07.017" target="_blank" >http://dx.doi.org/10.1016/j.toxlet.2012.07.017</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

In vitro inhibition of mitochondrial respiratory rate by antidepressants

Original language description

We investigated the in vitro effects of amitriptyline, fluoxetine, tianeptine, ketamine, lithium, valproate, olanzapine, chlorpromazine and propranolol on mitochondrial respiration in crude mitochondrial fraction of pig brains. Antidepressants, but not mood stabilizers, ketamine and propranolol, were found to inhibit mitochondrial respiratory rate. Our findings suggest that mood stabilizers do not interfere with brain mitochondrial respiration, whereas direct mitochondrial targeting of psychopharmacologically different antidepressants is probably involved in their mechanisms of action.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Toxicology Letters

ISSN

0378-4274

e-ISSN

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Volume of the periodical

213

Issue of the periodical within the volume

3

Country of publishing house

IE - IRELAND

Number of pages

8

Pages from-to

345-352

UT code for WoS article

000309170300006

EID of the result in the Scopus database

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