New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11714" target="_blank" >RIV/00216208:11110/12:11714 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s10787-011-0111-7" target="_blank" >http://dx.doi.org/10.1007/s10787-011-0111-7</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors

Original language description

This paper reviews new drug targets in the treatment of depression and new drug candidates to treat depression. We suppose that antidepressants tend to normalize six main pathways. Targeting these pathways has the potential to yield antidepressant effects, e.g. using cytokine antagonists, Cox-2 inhibitors, statins, acetylsalicylic acid, ketamine, omega3 poly-unsaturated fatty acids, antioxidants, and neurotrophic factors. We suggest that novel therapies could be developed that target these six pathwayssimultaneously.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Inflammopharmacology

ISSN

0925-4692

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

24

Pages from-to

127-150

UT code for WoS article

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EID of the result in the Scopus database

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