Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11753" target="_blank" >RIV/00216208:11110/12:11753 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:11753
Result on the web
<a href="http://dx.doi.org/10.1016/j.clineuro.2012.02.014" target="_blank" >http://dx.doi.org/10.1016/j.clineuro.2012.02.014</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Interferon, azathioprine and corticosteroids in multiple sclerosis: 6-year follow-up of the ASA cohort
Original language description
Objective: To evaluate long-term effects of 2-year treatment with interferon beta combined with low-dose azathioprine and prednisone in multiple sclerosis. Methods: In the original 2-year ASA study, 181 patients with early relapsing-remitting multiple sclerosis were randomised into 3 treatment arms: those treated with interferon beta (n = 60), with interferon beta and low-dose azathioprine (n =58), and interferon beta, azathioprine and low-dose prednisone (n = 63). Of these, 172 were included in this 4-year non-study extension. Three monthly clinical controls and annual MRI scans were carried out. The primary endpoint was annual relapse activity. The secondary endpoints were disability and quantitative MRI parameters. Results: Nine patients were lost to follow-up and 172 were included in the analyses. None of relapse activity, disability accumulation or MRI parameters differed significantly between the groups over 6 years. Only 5.5% and 0.6% of patients were free from disease activity
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurology and Neurosurgery
ISSN
0303-8467
e-ISSN
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Volume of the periodical
114
Issue of the periodical within the volume
7
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
940-946
UT code for WoS article
000307855800020
EID of the result in the Scopus database
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