Disturbance of real space navigation in moderately advanced but not in early Huntington's disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11918" target="_blank" >RIV/00216208:11110/12:11918 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8035 RIV/00159816:_____/12:#0001019 RIV/00064203:_____/12:8035 RIV/00064165:_____/12:11918
Result on the web
<a href="http://dx.doi.org/10.1016/j.jns.2011.08.016" target="_blank" >http://dx.doi.org/10.1016/j.jns.2011.08.016</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Disturbance of real space navigation in moderately advanced but not in early Huntington's disease
Original language description
Background: Visuospatial skills including spatial navigation are known to be impaired in Huntington's disease. Spatial navigation comprises two navigational frameworks, allocentric and egocentric. Several studies have associated the allocentric navigation with the hippocampus and the egocentric navigation with the striatum. The striatum is predominantly impaired from the early stages of Huntington's disease. Objective: To find whether spatial navigation impairment is present in the early stages of Huntington's disease and to test the hypothesis that the egocentric navigation is predominantly affected compared to the allocentric navigation. Methods: In nineteen patients with Huntington's disease the egocentric and the allocentric navigation skills weretested using the Blue Velvet Arena, a human analog of Morris Water Maze, and compared to nineteen age and gender-matched healthy controls. Cognitive functions, with emphasis on the executive functions, were also assessed. Results: The spa
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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