Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A11931" target="_blank" >RIV/00216208:11110/12:11931 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/12:00379750 RIV/75010330:_____/12:00009786 RIV/00216208:11130/12:8194 RIV/00023001:_____/12:00055955 RIV/00064165:_____/12:11931

Result on the web

<a href="http://dx.doi.org/10.1002/ijc.27412" target="_blank" >http://dx.doi.org/10.1002/ijc.27412</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer

Original language description

Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1) enzymes, both involved in bilirubin homeostasis, play an important role in the oxidative stress defense. The objective of our study was to assess the effect of promoter variations of HMOX1 and UGT1A1 genes and of serum bilirubin on the risk of sporadic colorectal cancer (CRC). This exploratory case-control study was based on 777 CRC patients and 986 controls from the Czech Republic. The (GT)n and (TA)n dinucleotide variations inHMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis. In addition, the A(-413)T variant in HMOX1 promoter was also analyzed using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Serum bilirubin levels were compared in a subset of 174 cases and 247 controls, for whom biochemical data were available. After adjustment for age, a significant association between CRC risk and UGT1A1*28 allele carrier status was detected [o

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Cancer

ISSN

0020-7136

e-ISSN

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Volume of the periodical

131

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

1549-1555

UT code for WoS article

000306915700022

EID of the result in the Scopus database

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