A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12005" target="_blank" >RIV/00216208:11110/12:12005 - isvavai.cz</a>

Alternative codes found

RIV/61989592:15110/12:10224485

Result on the web

<a href="http://dx.doi.org/10.1093/hmg/ddr479" target="_blank" >http://dx.doi.org/10.1093/hmg/ddr479</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23

Original language description

Renal cell carcinoma (RCC) is the most lethal urologic cancer. Only two common susceptibility loci for RCC have been confirmed to date. To identify additional RCC common susceptibility loci, we conducted an independent genome- wide association study (GWAS). We analyzed 533 191 single nucleotide polymorphisms (SNPs) for association with RCC in 894 cases and 1516 controls of European descent recruited from MD Anderson Cancer Center in the primary scan, and validated the top 500 SNPs in silico in 3772 cases and 8505 controls of European descent involved in the only published GWAS of RCC. It has been recently identified that one of the variants, rs718314 in ITPR2 is associated with waist-hip ratio (WHR) phenotype. To our knowledge, this is the first genetic locus associated with both cancer risk and WHR.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

R - Projekt Ramcoveho programu EK

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Molecular Genetics

ISSN

0964-6906

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

456-462

UT code for WoS article

000298658300019

EID of the result in the Scopus database

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