Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12068" target="_blank" >RIV/00216208:11110/12:12068 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:12068
Result on the web
<a href="http://dx.doi.org/10.1007/s00415-011-6275-7" target="_blank" >http://dx.doi.org/10.1007/s00415-011-6275-7</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Additional efficacy endpoints from pivotal natalizumab trials in relapsing-remitting MS
Original language description
Standard clinical endpoints in multiple sclerosis (MS) studies, such as disability progression defined by the expanded disability status scale (EDSS) and annualized relapse rate, may not fully reflect all aspects of therapeutic benefit experienced by patients. Pivotal studies showed that natalizumab is effective both as monotherapy (AFFIRM study) and in combination with interferon beta-1a (IFN beta-1a) (SENTINEL study) in patients with relapsing MS. We present AFFIRM and SENTINEL data demonstrating theefficacy of natalizumab on prespecified tertiary endpoints, including extent of confirmed change in EDSS score from baseline, time to sustained progression to EDSS milestone scores, hospitalizations, corticosteroid use, and time to confirmed progressionof cognitive deficits. Natalizumab significantly reduced changes in EDSS scores (P < 0.001) and proportion of patients progressing to an EDSS score a parts per thousand yen4.0 (P < 0.001) and a parts per thousand yen6.0 (P = 0.002) compar
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neurology
ISSN
0340-5354
e-ISSN
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Volume of the periodical
259
Issue of the periodical within the volume
5
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
898-905
UT code for WoS article
000304447900013
EID of the result in the Scopus database
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