Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12125" target="_blank" >RIV/00216208:11110/12:12125 - isvavai.cz</a>

Result on the web

<a href="http://fb.cuni.cz/file/5647/FB2012A0020.pdf" target="_blank" >http://fb.cuni.cz/file/5647/FB2012A0020.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Limitations of Macroscopic Fluorescence Imaging for the Estimation of Tumour Growth in an Orthotopic Glioma Mouse Model

Original language description

Imaging methods based on light detection are being increasingly used for assesment of tumor growth in animal models. There are no studies assesing macroscopic FLI for monitoring of tumor growth in glioma mouse model. Human glioma cells expressing mKate2were implanted to the brain of imunodeficient mouse. The tumor size was estimated by FLI and volume determined morphometrically. The fluorescent signal did not significantly correlate with the tumor volume. Therefore planar fluorescence imaging appearasto be suitable for semi-quantitative assesment of tumor growth rather then for precise volume estimation of xenografts located deep within the brain tissue.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

58

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

128-133

UT code for WoS article

000306098400006

EID of the result in the Scopus database

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