Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12394" target="_blank" >RIV/00216208:11110/12:12394 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/12:#0000218 RIV/00064165:_____/12:12394 RIV/00023728:_____/12:#0004140

Result on the web

<a href="http://dx.doi.org/10.1530/EJE-11-1047" target="_blank" >http://dx.doi.org/10.1530/EJE-11-1047</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Low-dose estrogen combined oral contraceptives may negatively influence physiological bone mineral density acquisition during adolescence

Original language description

Background: The aim was to evaluate changes of bone mineral density (BMD) and markers of bone turnover in healthy adolescents, and in adolescent users of combined oral contraceptives (COCs) with different ethinylestradiol (EE) contents. Methods: In thisprospective crossover study, 56 healthy females (15-19.5 years) with desire to use hormonal contraception were randomized to COC with either 30 or 15 mu g of EE in crossover design of 9-month intervention each in reverse order. Nonusers of the same age (n=28) served as controls. BMD at lumbar spine (LS), total femur, femoral neck, distal radius, and total body, and serum markers (N-propeptide of type I procollagen, and type I collagen C-telopeptide) were measured at baseline and after 9 and 18 months. Results: In COC nonusers, BMD significantly increased at LS and radius, while markers decreased. In COC users, BMD did not increase, with the exception of LS BMD in the 30 mu g COC group (P<0.05). In the crossover design, a difference betw

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Endocrinology

ISSN

0804-4643

e-ISSN

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Volume of the periodical

166

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

1003-1011

UT code for WoS article

000304541100006

EID of the result in the Scopus database

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