Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12690" target="_blank" >RIV/00216208:11110/12:12690 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:12690
Result on the web
<a href="http://dx.doi.org/10.1093/glycob/cws050" target="_blank" >http://dx.doi.org/10.1093/glycob/cws050</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Glycosphingolipid profile of the apical pole of human placental capillaries: The relevancy of the observed data to Fabry disease
Original language description
Immunohistochemical study performed in a series of full-term placentas and umbilical cords showed uniform distinct staining of the apical membrane of villous capillary endothelial cells for globotriaosylceramide (Gb3Cer), GM1 ganglioside, GM3 ganglioside, cholesterol and caveolin 1. The immunophenotype suggests the presence of caveola-associated raft microdomains. In situ analysis of glycosphingolipids was paralleled by biochemical analysis and tandem mass spectrometry. The lipid in situ profile of placental villous capillaries was compared with that of endothelial cells of the uteroplacental vessels, umbilical vessels and with that in somatic capillaries. Gb3Cer expression in the placental blood villous capillaries represents a unique finding which points to specific features of their endothelial apical pole.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EA - Morphology and cytology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10342" target="_blank" >NS10342: Biochemistry and Cell Biology of Human Acetyl-Coenzyme A: Alpha-Glucosaminide N-Acetyltransferase ? Basis for Future Therapeutic Applications in Mucopolysaccharidosis type IIIC</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Glycobiology
ISSN
0959-6658
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
725-732
UT code for WoS article
000301976400013
EID of the result in the Scopus database
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