The BRCA1 alternative splicing variant Delta 14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12900" target="_blank" >RIV/00216208:11110/12:12900 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00378624 RIV/00064165:_____/12:12900
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellsig.2011.12.023" target="_blank" >http://dx.doi.org/10.1016/j.cellsig.2011.12.023</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The BRCA1 alternative splicing variant Delta 14-15 with an in-frame deletion of part of the regulatory serine-containing domain (SCD) impairs the DNA repair capacity in MCF-7 cells
Original language description
Our findings show that BRCA1 delta 14-15 is not able to functionally replace the full-length wt BRCA1 in the DDSB repair and indicate that the endogenously expressed BRCA1 alternative splicing variants may negatively influence genome stability and support the growing evidence of the pathological potential of the sequence variants generated by an altered or misregulated alternative splicing in the process of mammary malignant transformation.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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