Selenium: an important trace element and therapeutic adjunct in critical care
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A12918" target="_blank" >RIV/00216208:11110/12:12918 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/12:12918
Result on the web
<a href="http://dx.doi.org/10.5414/TE0X1250" target="_blank" >http://dx.doi.org/10.5414/TE0X1250</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Selenium: an important trace element and therapeutic adjunct in critical care
Original language description
Selenium (Se) is an important micronutrient affecting multiple physiologic functions. Low Se levels observed in a general population are mainly caused by its limited availability in the diet. Se, incorporated in seleno-enzymes, plays a key role in protection against oxidative stress, a principle phenomenon in inflammatory response and sepsis. Se levels decrease early in inflammation. This decrease is probably caused by destruction of the enzymes as well as redistribution of Se, and its consumption. Se and seleno-enzyme levels correlate well with biomarkers and severity of sepsis. This observation sparked a hypothesis that Se supplementation would restore Se levels, improving the morbidity and mortality in sepsis. Standard-dose supplementation did not normalize Se levels. In contrast, high-dose supplementation in systemic inflammation and sepsis restored Se levels and improved some biomarkers of sepsis in several small-scale early studies. Similar benefits were observed in both experime
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trace Elements and Electrolytes
ISSN
0946-2104
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
4
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
246-255
UT code for WoS article
000311070200004
EID of the result in the Scopus database
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