Bone grafts as vancomycin carriers in local therapy of resistant infections

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13095" target="_blank" >RIV/00216208:11110/12:13095 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8261 RIV/00064203:_____/12:8261
Result on the web
<a href="http://dx.doi.org/10.1007/s12223-011-0093-2" target="_blank" >http://dx.doi.org/10.1007/s12223-011-0093-2</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Bone grafts as vancomycin carriers in local therapy of resistant infections
Original language description
The level of an antibiotic capable of inhibiting the etiological agent at the site of infection is an essential prerequisite for successful antibiotic therapy. In some cases, locally applied antibiotics may compensate for limitations of systemic administration and shorten systemic therapy. We aimed at verifying to what extent vancomycin (Van) bound to ground bone grafts is usable in the treatment of serious infections. The levels of released Van significantly exceeded the Van minimum inhibitory concentration, which can suppress Van-sensitive staphylococci and Van intermediate Staphylococcus aureus, for the whole period of a 16-day measurement. Our results indicate that bone grafts can be used as Van carriers in therapy of osteomyelitis caused by Van-sensitive Staphylococcus strains.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FI - Traumatology and orthopaedics
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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