Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13366" target="_blank" >RIV/00216208:11110/12:13366 - isvavai.cz</a>
Alternative codes found
RIV/61383082:_____/12:#0000124 RIV/00216208:11130/12:8240 RIV/00064203:_____/12:8240
Result on the web
<a href="http://dx.doi.org/10.5301/ijao.5000099" target="_blank" >http://dx.doi.org/10.5301/ijao.5000099</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
Artificial liver support system reduces intracranial pressure more effectively than bioartificial system: an experimental study
Original language description
Objectives: Extracorporeal liver support (ELS) may play a role in bridging therapy in patients with acute liver failure (ALF). The aim of this study was to compare the influence of nonbiological and biological methods on intracranial pressure (ICP) in ananimal model of ALF. Methods: A surgical devascularization model of ALF in pigs (35-40 kg) was used. Elimination therapy started after the onset of hypoglycemia. Biochemical parameters (bilirubin, ammonia, lactate, etc.) as well as ICP and cerebral perfusion pressure (CPP) were monitored for 12 hours. Of the total 31 pigs with ALF, 14 animals were treated by fractionated plasma separation and absorption (FPSA), 10 were treated with a bioartificial liver (BAL), and 7 animals were used as a control group. Results: FPSA and BAL treatment started on average 3 hours 17 minutes and 2 hours 21 minutes, after devascularization and lasted for 5 hours 54 minutes and 5 hours 43 minutes, respectively. Ammonia levels were lower in the FPSA group, a
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Artificial Organs
ISSN
0391-3988
e-ISSN
—
Volume of the periodical
35
Issue of the periodical within the volume
7
Country of publishing house
IT - ITALY
Number of pages
8
Pages from-to
503-510
UT code for WoS article
000308522000004
EID of the result in the Scopus database
—