The influence of clonidine on oral ketamine-midazolam premedication in intellectually disabled patients indicated for dental procedures: Double-blind comparison of two sedation regimes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F12%3A13570" target="_blank" >RIV/00216208:11110/12:13570 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/12:43906585 RIV/00023001:_____/12:00056074 RIV/00023752:_____/12:43913806

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The influence of clonidine on oral ketamine-midazolam premedication in intellectually disabled patients indicated for dental procedures: Double-blind comparison of two sedation regimes

Original language description

BACKGROUND: Dental procedures on intellectually disabled patients represent a clinical challenge. The oral administration of sedating drugs can remediate the problems with cooperation and enable the medical procedures to take place. Standard guidelines are lacking for oral sedation of the intellectually disabled. OBJECTIVE: To compare two oral combinations of sedating drugs in terms of time to the onset and achievement of full sedation, vital signs, behavioral measures and safety. METHODS: In a group of29 intellectually disabled patients we compared two oral combinations for analgosedation: ketamine (5 mg/kg) - clonidine 2 mu g/kg - midazolam 0.3 mg/kg (N=17) or ketamine 5 mg/kg - midazolam 0.3 mg/kg (N= 12 patients). Drugs were dissolved in a sweet drink. RESULTS: Full sedation was achieved within 25 min. in 27 patients and serious side effects were not detected. Clonidine in combination with ketamine and midazolam did not exert any significant effect by means of the onset of sedatio

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

4

Country of publishing house

SE - SWEDEN

Number of pages

5

Pages from-to

380-384

UT code for WoS article

000310259500005

EID of the result in the Scopus database

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