Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10144061" target="_blank" >RIV/00216208:11110/13:10144061 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/13:43874846 RIV/00216208:11160/13:10144061 RIV/00179906:_____/13:10144061 RIV/00179906:_____/13:10218292
Result on the web
<a href="http://www.ingentaconnect.com/content/ben/loc/2013/00000010/00000004/art00011" target="_blank" >http://www.ingentaconnect.com/content/ben/loc/2013/00000010/00000004/art00011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570178611310040011" target="_blank" >10.2174/1570178611310040011</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of Novel Tacrine and 7-MEOTA Derivatives with Aromatic and Alicyclic Residues: Synthesis, Biological Evaluation and Docking Studies
Original language description
Cholinesterase inhibitors play an essential role in the treatment of Alzheimer's disease. Since their first introduction over a decade ago, they are an indispensable part of Alzheimer's disease therapy and remain at the forefront of scientific interest worldwide. In this manuscript new analogs of THA and 7-MEOTA were designed, synthesized, and evaluated for their inhibitory activity against both acetylcholinesterase and butyrylcholinesterase. Cholinergic properties were investigated and quantified withrespect to their side chain residues (aromatic or alicyclic). All synthesized compounds proved to have potent inhibitory activity at micromolar range. Moreover, compound 4 demonstrated promising efficacy and appears to be an ideal candidate for further testing.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP303%2F11%2F1907" target="_blank" >GAP303/11/1907: Novel inhibitors of acetylcholinesterase derived from 7-MEOTA - potential Alzheimer´s disease drugs</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Letters in Organic Chemistry
ISSN
1570-1786
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
4
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
7
Pages from-to
291-297
UT code for WoS article
000318689200010
EID of the result in the Scopus database
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