Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173660" target="_blank" >RIV/00216208:11110/13:10173660 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10173660

Result on the web

<a href="http://dx.doi.org/10.1093/ndt/gfs439" target="_blank" >http://dx.doi.org/10.1093/ndt/gfs439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfs439" target="_blank" >10.1093/ndt/gfs439</a>

Result language

angličtina

Original language name

Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy

Original language description

Background. Antibodies against M-type phospholipase A(2) receptor (PLA2R) are serological markers of disease activity in patients with idiopathic membranous nephropathy (iMN). To determine the most sensitive test for the diagnosis of PLA2-Rrelated membranous nephropathy (MN) irrespective of sampling time, we investigated the presence of PLA2R in glomerular immune deposits and assessed circulating anti-PLA2R antibodies in a retrospective cohort of Czech patients with idiopathic, lupus and other few secondary MN. Methods. We tested archival paraffin-embedded kidney biopsies of 84 consecutive patients with biopsy-proven MN, for the presence of PLA2R in glomerular immune deposits and we measured circulating anti-PLA2R antibodies using the indirect immunofluorescence test, all reagents being commercially available. Results. In 45 of 65 (69%) patients with iMN, PLA2R was detected in a finely granular pattern in sub-epithelial deposits along glomerular capillary loops. Circulating anti-PLA2R

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nephrology Dialysis Transplantation

ISSN

0931-0509

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

7

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

1839-1844

UT code for WoS article

000321821900029

EID of the result in the Scopus database

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