Recent insights into the pathogenesis of nephrotic syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173677" target="_blank" >RIV/00216208:11110/13:10173677 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/13:10173677

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Recent insights into the pathogenesis of nephrotic syndrome

Original language description

Nephrotic syndrome is characterized by heavy proteinuria followed by hypoproteinemia, hypercholestrolemia, lipiduria, and edema. The glomerular filtration barrier (GFB) consists of glomerular endothelial cells covered with glycocalyx, the basement membrane, subpodocyte space and podocytes with foot processes and slit membranes between them. The coordinated function of GFB has been considered to be the major barrier against filtration of plasma proteins to urine. However, new hypothesis suggesting more permeable GFB has emerged. According to this, proteinuria might be prevented by tubular protein reabsorbtion. Experments and human studies have revealed numerous putative permeability factors in idiopathic nephrotic syndrome (minimal change disease/focalsegmental glomerulosclerosis). New antigens and antibodies have been suggested in "idiopathic" membranous nephropathy as well. Formation of nephrotic edema, the role of oncotic pressure and of different sodium and water retaining hormones

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Minerva Medica

ISSN

0026-4806

e-ISSN

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Volume of the periodical

104

Issue of the periodical within the volume

3

Country of publishing house

IT - ITALY

Number of pages

15

Pages from-to

333-347

UT code for WoS article

000322930300009

EID of the result in the Scopus database

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