Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10173743" target="_blank" >RIV/00216208:11110/13:10173743 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/13:10173743 RIV/00064203:_____/13:10173743 RIV/00023736:_____/13:00009659 RIV/00064165:_____/13:10173743
Result on the web
<a href="http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x" target="_blank" >http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1600-0714.2012.01185.x" target="_blank" >10.1111/j.1600-0714.2012.01185.x</a>
Alternative languages
Result language
angličtina
Original language name
Loss of adhesion/growth-regulatory galectin-9 from squamous cell epithelium in head and neck carcinomas
Original language description
Galectins are potent effectors of cell adhesion and growth regulation. Their expression as comples network necessitates systematic study of each member of this family. Toward this aim, we here focus on the tandem-repeat-type galectin-9. Its presence is monitored in normal squamous epithelium of the head and neck, the surgical margin, and four types of squamous cell carcinoma. Lectin presence was detected in cells of the basal layer of the epithelium. All galectin-9-negative epithelia showed aberrant positivity for keratins 14 and 19. The surgical margin presented either a normal pattern of galectin-9 and keratin presence or a mosaic-like presence/absence of galectin-9 and aberrant expression of both keratins 14 and 19. All studied specimens of squamouscell carcinoma were negative for galectin-9. When biotinylated galectin-9, or its N-terminal domain, was tested, no significant tissue reactivity for both probes was observed. Neuraminidase treatment generated reactivity to the N-domain.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Oral Pathology and Medicine
ISSN
0904-2512
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
166-173
UT code for WoS article
000314471200008
EID of the result in the Scopus database
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