Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10174139" target="_blank" >RIV/00216208:11110/13:10174139 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1517/14728222.2013.750651" target="_blank" >http://dx.doi.org/10.1517/14728222.2013.750651</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1517/14728222.2013.750651" target="_blank" >10.1517/14728222.2013.750651</a>
Alternative languages
Result language
angličtina
Original language name
Context-dependent multifunctionality of galectin-1: a challenge for defining the lectin as therapeutic target
Original language description
Introduction: One route of translating the information encoded in the glycan chains of cellular glycoconjugates into physiological effects is via receptor (lectin) binding. A family of endogenous lectins, sharing folding, a distinct sequence signature and affinity for beta-galactosides (thus termed galectins), does so effectively in a context-dependent manner. Areas covered: An overview is given on the multifunctional nature of galectins, with emphasis on galectin-1. The broad range of functions includes vital processes such as adhesion via glycan bridging, glycoconjugate transport or triggering signaling relevant, for example, for growth regulation. Besides distinct glycoconjugates, this lectin can also interact with certain proteins so that it can target counterreceptors at all sites of location, that is, in the cytoplasm and/or nucleus, at both sides of the membrane or extracellularly. Approaches to strategically exploit galectin activities with therapeutic intentions are outlined.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Expert Opinion on Therapeutic Targets
ISSN
1472-8222
e-ISSN
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Volume of the periodical
17
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
379-392
UT code for WoS article
000316127600005
EID of the result in the Scopus database
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