Minimal residual disease detectable by quantitative assessment of WT1 gene before allogeneic stem cell transplantation in patients in first remission of acute myeloid leukemia has an impact on their future prognosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188740" target="_blank" >RIV/00216208:11110/13:10188740 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/13:00010528 RIV/00064165:_____/13:10188740

Result on the web

<a href="http://dx.doi.org/10.1111/ctr.12046" target="_blank" >http://dx.doi.org/10.1111/ctr.12046</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ctr.12046" target="_blank" >10.1111/ctr.12046</a>

Result language

angličtina

Original language name

Minimal residual disease detectable by quantitative assessment of WT1 gene before allogeneic stem cell transplantation in patients in first remission of acute myeloid leukemia has an impact on their future prognosis

Original language description

Overall 42 patients (pts) transplanted in hematological CR1 were retrospectively analyzed. Median follow-up was 15 months (range 277). The expression of WT1 gene was measured according to the European Leukaemia Net recommendations. At the time of allogeneic stem cell transplantation (allo-SCT) 29 pts were WT1-negative and 13 pts were WT1-positive. In the univariate analysis, significantly better results were observed in the group of WT1 neg in terms of progression-free survival (in three yr 77% vs. 27%,p = 0.001). In multivariate analysis, the only significant feature in terms of better OS was WT1 negativity (p = 0.029). Our results show that minimal residual disease status measured by quantitative assessment of WT1 gene in acute myeloid leukemia ptsin CR1 significantly affects their future prognosis after allo-SCT.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NT11299" target="_blank" >NT11299: Quality of life measurement and its influence to overall survival in hematopoietic stem cell transplantation in CZ</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Transplantation

ISSN

0902-0063

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

"E21"-"E29"

UT code for WoS article

000314208000007

EID of the result in the Scopus database

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