Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10188970" target="_blank" >RIV/00216208:11110/13:10188970 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/jnci/djt053" target="_blank" >http://dx.doi.org/10.1093/jnci/djt053</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/jnci/djt053" target="_blank" >10.1093/jnci/djt053</a>

Result language
angličtina
Original language name
Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study
Original language description
Human papillomavirus (HPV) is causally implicated in a subset of cancers of the upper aero-digestive tract (UADT). Associations between type-specific HPV antibodies were examined among 1496 UADT cancer case subjects and 1425 control subjects by estimating odds ratios (ORs) in logistic regression analyses adjusted for potential confounders. The agreement between serology and tumor markers of HPV infection, including presence of HPV DNA and p16 expression, were examined in a subset of tumors. HPV16 L1 seropositivity was associated with increased risk of oral cavity and oropharyngeal cancer (OR 1.94, 95% confidence interval [CI] 1.03 to 3.65; OR 8.60, 95% CI 5.21 to 14.20, respectively). HPV16 E6 antibodies were present in 30.2% of oropharyngeal case subjects and only 0.8% of control subjects (OR 132.0, 95% CI 65.29 to 266.86). Combined seropositivity to HPV16 E6 and E7 was rare (n 1 of 1425 control subjects). An agreement of 67% was observed between HPV16 E6 serology and the correspondin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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