All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189436" target="_blank" >RIV/00216208:11110/13:10189436 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bbmt.2013.02.012" target="_blank" >http://dx.doi.org/10.1016/j.bbmt.2013.02.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bbmt.2013.02.012" target="_blank" >10.1016/j.bbmt.2013.02.012</a>

Result language

angličtina

Original language name

All Hematopoietic Stem Cells Engraft in Submyeloablatively Irradiated Mice

Original language description

Significant controversy exists regarding the impact of hematopoietic stroma damage by irradiation on the efficiency of engraftment of intravenously transplanted stem cells. It was previously demonstrated that in normal syngenic mice, all intravenously transplanted donor stem cells, present in the bone marrow, compete equally with those of the host. In this study, we comprehensively compared the blood cell production derived from transplanted donor stem cells with that from the host stem cells survivingvarious doses of submyeloablative irradiation. We compared the partial chimerism resulting from transplantation with theoretical estimates that assumed transplantation efficiencies ranging from 100% to 20%. The highest level of consensus between the experimental and the theoretical results was 100% for homing and engraftment (ie, the utilization of all transplanted stem cells). These results point to a very potent mechanism through which intravenously administered hematopoietic stem cell

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

<a href="/en/project/LC06044" target="_blank" >LC06044: Center for Experimental Hematology</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biology of Blood and Marrow Transplantation

ISSN

1083-8791

e-ISSN

—

Volume of the periodical

19

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

713-719

UT code for WoS article

000318132500006

EID of the result in the Scopus database

—