The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189444" target="_blank" >RIV/00216208:11110/13:10189444 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/13:00394829

Result on the web

<a href="http://dx.doi.org/10.1007/s11302-012-9340-5" target="_blank" >http://dx.doi.org/10.1007/s11302-012-9340-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11302-012-9340-5" target="_blank" >10.1007/s11302-012-9340-5</a>

Result language

angličtina

Original language name

The pharmacological activation of adenosine A(1) and A(3) receptors does not modulate the long- or short-term repopulating ability of hematopoietic stem and multipotent progenitor cells in mice

Original language description

This study continues our earlier findings on the hematopoiesis-modulating effects of adenosine A(1) and A(3) receptor agonists that were performed on committed hematopoietic progenitor and precursor cell populations. In the earlier experiments, N (6)-cyclopentyladenosine (CPA), an adenosine A(1) receptor agonist, was found to inhibit proliferation in the above-mentioned hematopoietic cell systems, whereas N (6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA), an adenosine A(3) receptor agonist, was found to stimulate it. The topic of this study was to evaluate the possibility that the above-mentioned adenosine receptor agonists modulate the behavior of early hematopoietic progenitor cells and hematopoietic stem cells. Flow cytometric analysis ofhematopoietic stem cells in mice was employed, as well as a functional test of hematopoietic stem and progenitor cells (HSPCs). These techniques enabled us to study the effect of the agonists on both short-term repopulating ability and l

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Purinergic Signalling

ISSN

1573-9538

e-ISSN

—

Volume of the periodical

9

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

207-214

UT code for WoS article

000318559800008

EID of the result in the Scopus database

—