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Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189655" target="_blank" >RIV/00216208:11110/13:10189655 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985807:_____/13:00425961 RIV/00216208:11310/13:10189655

  • Result on the web

    <a href="http://fb.cuni.cz/file/5699/FB2013A0026.pdf" target="_blank" >http://fb.cuni.cz/file/5699/FB2013A0026.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Serum Levels of Matrix Metalloproteinases 2 and 9 in Patients with Acute Myocardial Infarction

  • Original language description

    The myocardial extracellular matrix plays an important role in maintaining the structural and functional integrity of the heart and is centrally involved in post-myocardial infarction repair processes. We analysed some genetic and proteomic aspects thatcould play an important role in the development of myocardial infarction. Matrix metalloproteinases are enzymes that contribute strongly to the degradation of extracellular matrix components. In this study the serological levels of MMP-2 and MMP-9 were investigated using immunological testing in 34 patients with myocardial infarction and 34 matched control subjects. The serum levels of WIMPs were determined by ELISA. Changes in serum levels were characterized within 24 h and after 6 months post myocardial infarction. Significantly higher levels of MMP-2 (299.47 +/- 117.61 ng/ml) and MMP-9 (93.56 +/- 53.74 ng/ml) were determined in patients with myocardial infarction compared to the controls, in both cases P < 0.001. MMP-9 levels decreas

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FA - Cardiovascular diseases including cardio-surgery

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/1M06014" target="_blank" >1M06014: Centre of Biomedical Informatics</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Folia Biologica

  • ISSN

    0015-5500

  • e-ISSN

  • Volume of the periodical

    59

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    181-187

  • UT code for WoS article

    000327577300002

  • EID of the result in the Scopus database