Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190200" target="_blank" >RIV/00216208:11110/13:10190200 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/13:#0000399 RIV/00064165:_____/13:10190200
Result on the web
<a href="http://dx.doi.org/10.1016/j.regpep.2012.12.010" target="_blank" >http://dx.doi.org/10.1016/j.regpep.2012.12.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.regpep.2012.12.010" target="_blank" >10.1016/j.regpep.2012.12.010</a>

Result language
angličtina
Original language name
Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women
Original language description
Objective: Free fatty acids (FFA)-adrenocorticotropin (ACTH) feedback loop between adipose tissue and the hypothalamic-pituitary centers in the brain has been suggested to be affected by the exercise and by administration of anti-lipolytic drugs. Also leptin may be affected by exercise. Dysfunction of FFA-leptin-ACTH secretion might be involved in binge eating and subsequent purging as is the case in bulimia nervosa (BN). Methods: In the present single-blind, randomized study, we explored responses of plasma ACTH, leptin and FFA concentrations to exercise (45 min, 2 W/kg of lean body mass [LBM]) with Acipimox (Aci), an anti-lipolytic nicotinic acid analog, or placebo randomly received in nine women with EN and nine healthy women. In conclusion, Aci canbe considered acceptable in the treatment of eating disorders, and it may also serve as an alternative low-dose dexamethasone suppression test (LDDST) in these patients. Trial registration: Australia and New Zealand Clinical Trials Regis
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NR9158" target="_blank" >NR9158: Postprandial response of ghrelin and other appetite-modulating hormones in patients with anorexia nervosa and bulimia nervosa</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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