Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190240" target="_blank" >RIV/00216208:11110/13:10190240 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/13:43907457 RIV/00064173:_____/13:#0000338 RIV/00023752:_____/13:43914444 RIV/00064165:_____/13:10190240
Result on the web
<a href="http://dx.doi.org/10.1016/j.jneuroim.2013.03.009" target="_blank" >http://dx.doi.org/10.1016/j.jneuroim.2013.03.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2013.03.009" target="_blank" >10.1016/j.jneuroim.2013.03.009</a>
Alternative languages
Result language
angličtina
Original language name
Serum and cerebrospinal fluid heavy neurofilaments and antibodies against them in early multiple sclerosis
Original language description
Heavy neurofilaments (NFH) released from neurons during axonal injury induce a humoral immune response. We measured CSF and serum levels of NFH proteins and anti-NFH IgG antibodies in 19 patients with clinically isolated syndrome (CIS) converting to multiple sclerosis, in 20 stable CIS patients, 23 patients with multiple sclerosis (MS) and 32 control subjects using ELISA. CSF and intrathecal levels and CSF/serum ratios of anti-NFH antibodies were increased in the CIS patients early developing MS while NFH protein concentrations were similar among the groups. Changes associated with NFH are more pronounced for antibodies than for protein itself and may aid in prediction of CIS patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13183" target="_blank" >NT13183: Brief psychometric instruments for early diagnosis of Alzheimer's disease in senior population</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroimmunology
ISSN
0165-5728
e-ISSN
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Volume of the periodical
259
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
81-87
UT code for WoS article
000319848100010
EID of the result in the Scopus database
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