Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10190951" target="_blank" >RIV/00216208:11110/13:10190951 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/13:10190951
Result on the web
<a href="http://dx.doi.org/10.1038/gene.2013.17" target="_blank" >http://dx.doi.org/10.1038/gene.2013.17</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/gene.2013.17" target="_blank" >10.1038/gene.2013.17</a>

Result language
angličtina
Original language name
Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome
Original language description
It has not yet been established whether genetic predictors of multiple sclerosis (MS) susceptibility also influence disease severity and accumulation of disability. Our aim was to evaluate associations between 16 previously validated genetic susceptibility markers and MS phenotype. Patients with clinically isolated syndrome verified by positive magnetic resonance imaging (MRI) and cerebrospinal fluid findings (n = 179) were treated with interferon-beta. Disability and volumetric MRI parameters were evaluated regularly for 2 years. Sixteen single-nucleotide polymorphisms (SNPs) previously validated as predictors of MS susceptibility in our cohort and their combined weighted genetic risk score (wGRS) were tested for associations with clinical (conversionto MS, relapses and disability) and MRI disease outcomes (whole brain, grey matter and white matter volumes, corpus callosum cross-sectional area, brain parenchymal fraction, T2 and T1 lesion volumes) 2 years from disease onset using mix
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
<a href="/en/project/NT13237" target="_blank" >NT13237: Clinical and paraclinical markers of multiple sclerosis – description and prediction of disease activity</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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